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Best Diet Pills 2023: Top 7 Weight Loss Supplements That Actually Work


Reviewed by Dr. Drew Sutton, MD
best diet pills
There are some top diet supplements for weight loss. Photo: Team Design

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There are a lot of diet pills for weight loss on the market right now. Some of them may not even do anything. It’s hard to tell which are the best diet pills, but this list should help! Of course, it’s only a starting point, and you need to make sure to do your own research as well, but we’ve done our best to compile the good and the bad of each option, so you know exactly what to look for.

How does a diet pill work? There are a few different types of compounds found in these prescription weight-loss medications, and the brand will usually combine the effects of several to be more powerful. Most alter your appetite, making you feel more full with less food or decreasing your cravings. Some pills also help you lose weight by blocking you from creating fat or speeding up your metabolism so stubborn body fat burns faster. The best pills combine several of these functions.

Best Weight Loss Pills 2023

The features we looked for in choosing these products include natural, vegan, and allergy-friendly compounds, price, levels of caffeine and other stimulants, shipping and money-back information, and third-party testing and reliability.

Best Diet Pills 2023


  • Vegan
  • Good money-back guarantee
  • Few side effects
  • No synthetic additives
  • Free shipping globally
  • Not suitable for children or pregnant or nursing mothers
  • Has a large amount of caffeine

PhenQ is a very reputable and reliable weight loss pill. Their formula includes five great effects: it burns fat, blocks the production of further fat of body weight, suppresses appetite, increases energy levels, and improves your mood. Their brand is well known and has few reported complaints of side effects or contamination. The ingredients are reliable and clinically backed.

You should take two pills per day, one with breakfast and one with lunch. There is a thirty-day supply in each bottle or sixty pills. Shipping is free anywhere in the world, and there are very good discounts for buying in large quantities. Unfortunately, it does have fairly high amounts of caffeine for increased energy.


  • Formulated for women
  • Caffeine-free
  • Vegan, gluten-free, soy-free, non-GMO, and organic
  • Testing results are available online
  • 90-day money-back guarantee
  • Complicated return policy
  • Six pills each day
  • Results can be delayed and may vary

LeanBean is fantastic for any kind of sensitivity. It has no caffeine at all, which is a massive win for people with caffeine sensitivities. It’s also gluten-free, soy-free, organic, non-GMO, and vegan.

The pill’s results vary quite a bit from person to person and depend on body mass index (BMI), although that is also true for most weight loss supplements. With their money-back guarantee, you can try it for a while before you commit (although some people have said the return process is difficult and confusing). 

You have to take a large number of the capsules – two each before breakfast, lunch, and dinner, for six total in a day. Each jar has a month’s worth of capsules, and large orders come with bulk discounts and free shipping. 

Instant Knockout

  • Good for athletes
  • Vegan
  • FDA and GMCA registered facility
  • No proprietary secret ingredients
  • Can be expensive
  • Has a high concentration of caffeine
  • Shouldn’t be taken with other supplements that contain stimulants

Instant Knockout is a serious, powerful, effective weight loss supplement. The high concentrations of caffeine are better for men than for women, although women can also use it. The ingredients are all-natural, and it works very well as an appetite suppressant and a metabolism booster. 

One of the best features of Instant Knockout is its transparency. There are no proprietary blends or secret ingredients. Unlike some popular weight loss pills, Instant Knockout doesn’t have artificial sweeteners. The fist-shaped bottle is just a fun bonus!

It’s designed to be taken four times a day: once early in the morning and once before each meal. Be careful not to eat supper too late in the evening, or the caffeine might interfere with your sleep. 


  • Good money-back guarantee
  • FDA registered facility
  • Fast and reliable shipping
  • No proprietary, secret ingredients
  • High concentration of caffeine
  • Can be expensive
  • The availability is limited to certain countries

PhenGold contains no synthetic materials; all ingredients are natural. It has several effects; it suppresses appetite, encourages fat burning, and speeds up the metabolism. There are no proprietary ingredients, so you can understand what each ingredient does.

It contains a fair amount of caffeine, but not as large a dose as some of the others. It’s designed for you to take three pills each day, and each bottle is a one-month supply. PhenGold is soy-free, gluten-free, dairy-free, vegan, and non-GMO. PhenGold might not stand out of the pack, but it’s one of the most reliable brands there is and has lasted for a long time.


  • Lose excess weight without losing muscle
  • Backed by clinical research
  • Naturally grown, soy-free, gluten-free, non-GMO, and vegan
  • Sometimes causes upset stomachs
  • Can be expensive
  • Not safe for pregnant or breastfeeding women

PrimeShred advertises three significant effects: increasing fat-burning thermogenesis,[1] speeding up metabolism, and maintaining energy and focus. It contains high-quality natural ingredients, and every ingredient is transparently listed on the label.

There have been some unpleasant side effects noted for PrimeShred, though, and it’s not safe for women who are pregnant or nursing.


  • Clean ingredients
  • Money-back guarantee
  • Backed by clinical research
  • Works 24/7, avoiding cyclical crashes
  • The two-step process requires you to keep two bottles
  • Can be expensive

This twenty-four-hour system includes two different pills, one for the morning and one for the evening. The daytime pill, for example, increases metabolism and energy while decreasing appetite, while the nighttime pill decreases food cravings and cortisol levels to help with weight management and better sleep.  The ingredients are clean and transparent and include vitamins and minerals to enhance your overall health in addition to the weight loss features. It’s expensive, but its ability to work with your circadian rhythm makes it worth it. It’s also worth the extra space taken up by having two bottles.


  • Made for women
  • Suppresses the appetite
  • Only one pill a day
  • Not vegan
  • Not safe for pregnant or breastfeeding women
  • High levels of stimulants such as caffeine

TrimTone is the simplest pill on this list. With only one pill per day, it’s easy to change your habits. It works through appetite suppression, fat burning, and increasing energy and focus. 

However, it has a large amount of caffeine and other stimulants, which women can be more sensitive to than men. It’s also not vegan.

How To Choose The Best Diet Pills? 

Since every person reacts differently to various compounds, the best way to choose pills is to try them and see what works. Do your research beforehand to find out what ingredients are most important, whether you want caffeine or not, whether it’s important to you that the pills be vegan, and so on. 

Then choose a brand that fits those criteria and offers a few months of guaranteed returns if you’re not satisfied, and try it out! Return it if you don’t like it, and try another until you find what works best for you. 

The Most Effective Weight Loss Ingredients

Green Tea Extract

Green tea extract[2] boosts thermogenesis, especially when combined with exercise and other parts of a healthy lifestyle. In addition, it improves glucose tolerance[3] and helps oxidize fat.


Studies have shown that caffeine can help you lose weight,[4] but mostly when accompanied by a healthy diet and exercise. It aids in speeding up your metabolism, making exercise more effective. 


This is a difficult-to-pronounce ingredient derived from plants that have been cultivated for medicine in China for a long time. It’s effective in large quantities when paired with a calorie-restrictive diet.

Types Of Dietary Supplements For Weight Loss

There are prescription weight loss drugs,[5] which are often more effective than the over-the-counter version if your physician agrees you should use them. The alternative natural weight loss pills can be better if you want organic compounds and try to avoid synthesized chemicals as in prescription medications. 

Whether you choose prescription weight loss drugs or not is up to you and your preference. However, it’s worth noting that prescription weight loss drug is more likely to have adverse side effects than their natural, organic alternatives. 

Dosage And Safety

Always take the recommended dose. Never ever take a higher dose than recommended; most ingredients used in natural brands are relatively safe, but the doses they’ve been studied at are the doses the manufacturers will use. Don’t take too small a dose, either, or it will likely be ineffective.

How Much Do Diet Pills Cost?

This is a difficult question to answer since it varies depending on the brand and the ingredients. However, most pills cost around $50 to $100 for a month’s supply. You get what you pay for; if you find something drastically cheaper than that, it’s likely unreliable and certainly not one of the best weight loss pills. 

Final Thought

There are a lot of different pills to help you lose weight on the market, but we hope this guide helps you select the best options for yourself and your lifestyle!

Frequently Asked Questions (FAQs)

Are PhenQ, PhenGold, and Phen24 related?

All three are alternatives to the brand Phentermine, a prescription weight loss medication. They’re not produced by the same brand or are otherwise related.

Can you take more than one diet pill?

You should definitely not do that! These pills are designed to work alone, and most of them use the same ingredients so that you could get much too high a dose.

My diet pills are making me feel sick?

Keep an eye out for adverse effects. Trouble sleeping might mean your pill has too much caffeine, and being shaky or having low energy might mean the appetite suppressant is too intense and you’re not getting enough food. Stop taking the diet pills or find a different brand if you need to.

What’s the best pill?

What’s best varies from person to person. That’s why there are so many options; which pill is best depends on whether you need it to be vegan, whether caffeine bothers you, and many other variables.

+ 5 Sources

EHproject has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We work mostly with peer-reviewed studies to ensure accurate information. We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.

  1. Himms-Hagen, J. (1989). Role of thermogenesis in the regulation of energy balance in relation to obesity. Canadian Journal of Physiology and Pharmacology, [online] 67(4), pp.394–401. doi:10.1139/y89-063.
  2. Sabu Mandumpal Chacko, Thambi, P.T., Ramadasan Kuttan and Ikuo Nishigaki (2010). Beneficial effects of green tea: A literature review. Chinese Medicine, [online] 5(1), pp.13–13. doi:https://doi.org/10.1186/1749-8546-5-13.
  3. Venables, M.C., Hulston, C.J., Cox, H.R. and Jeukendrup, A.E. (2008). Green tea extract ingestion, fat oxidation, and glucose tolerance in healthy humans. The American Journal of Clinical Nutrition, [online] 87(3), pp.778–784. doi:10.1093/ajcn/87.3.778.
  4. Doherty, M. and Smith, P.M. (2005). Effects of caffeine ingestion on rating of perceived exertion during and after exercise: a meta-analysis. Scandinavian Journal of Medicine and Science in Sports, [online] 15(2), pp.69–78. doi:10.1111/j.1600-0838.2005.00445.x.
  5. Tchang, B.G., Aras, M., Kumar, R.B. and Aronne, L.J. (2021). Pharmacologic Treatment of Overweight and Obesity in Adults. [online] Nih.gov. Available at: https://www.ncbi.nlm.nih.gov/books/NBK279038/


Christine is a certified personal trainer and nutritionist with an undergraduate degree from Missouri State University. Her passion is helping others learn how strong and healthy they can become by transforming their daily habits. Christine spends… See More

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