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Noocube Review 2023 – Brain Booster Benefits, Safety & Efficacy

Rick Bayer

Reviewed by Dr. Drew Sutton, MD
Noocube Review
Noocube is a reputed and well-tested nootropic with all-natural ingredients. Photo: Team Design

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Brain disorders are the leading cause of disability and mortality in the Western world. What is worrisome is that these conditions are on the rise. Alzheimer’s disease[1] is now among the leading causes of mortality.

However, brain problems are not limited to neurodegeneration. More and more people complain about lower cognitive performance, poor brain health, mental fatigue, low mental energy, and brain fog.

Additionally, these days people are increasingly engaged in mental work. Thus, some look for supplements to support brain health, boost brain power, improve brain function, and improve mental clarity.

In the last few decades, the prevalence of metabolic disorders has risen considerably, along with the prevalence of brain disorders. There is now little doubt that lifestyle factors contribute significantly to brain health.

There are many ways to boost brain health and overall cognitive function. However, natural remedies are better. One of the excellent ways to improve mental health and memory is through the use of a brain booster, the Noocube nootropic supplement.

This supplement is unique in many ways. First, unlike other supplements that primarily stimulate neural function, this supplement affects the “gut-brain axis.” After all, it is now proven beyond doubt that the gut produces 90% of serotonin[2] and many other neurotransmitters.

In this Noocube review, we share the results of extensive testing of the Noocube brain supplement. Furthermore, this review shares both pros and cons and information about various options so that people can make an informed choice.



  • Caffeine and stimulants-free
  • GMO- and gluten-free
  • Accurate labeling
  • Unique proprietary blend
  • Takes about a week to feel the effect
  • Four capsules in a serving

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What Is Noocube?

Noocube is a reputed and well-tested nootropic with all-natural ingredients. It is a dietary supplement. It not only helps boost brain functions like memory but can also slow down neurodegeneration and brain aging. This makes it perfect for prolonged use.

It differs significantly from other nootropics in the market as it does not focus on stimulating neural function. Instead, this supplement focuses on the root cause of brain health issues. As a result, it is especially good for preventing brain disorders.

Does It Really Work?

Yes, it works for sure. However, unlike other nootropics, it tries to act on the root cause of cognitive disorders. Noocube is unique in many ways and can improve nerve growth, and mental health, boost memory, mental capabilities, and more. It is a unique brain supplement in many ways.

It is unlike other nootropics that contain stimulants or try to affect brain blood flow or metabolism directly. Instead, this supplement tries to modulate the gut-brain axis.[3]

New studies show that the gut has more say in brain health than believed earlier. As a result, many researchers think that perhaps the best way to prevent neurodegenerative disorders is to focus on gut health, promote microbiota, and production of long-chain fatty acids along with neurotransmitters.

Additionally, focusing on the gut can alter immune responses, lower inflammation, and have many other health benefits.

Noocube Ingredients

The “gut-brain axis” role in brain health is now recognized beyond doubt. Moreover, it is among the few brain health supplements that try to regulate this axis and thus boost brain health.

It contains prebiotics and probiotics and can help counter gut inflammation, prevent leaky gut syndrome, boost the production of neuropeptides, short-chain fatty acids, and more.

Noocube Ingredients
Noocube Ingredients List


It is a unique component of this nootropic, and this supplement contains 1000 mg. Thus, it is the most vital component of this supplement. Tributyrin breaks down into three molecules of butyrate in the small intestine. It promotes gut health, reduces inflammation, improves protein digestibility,[4] and influences lipid metabolism.

Thus, it can help improve mood and mental health, prevent brain fog, and reduce neurodegeneration risk. It is also suitable for metabolic health, reducing the risk of diabetes, and helps counter stress by lowering cortisol levels and modifying appetite and mood.


It is a hydrolyzed form of guar gum that is quite good for metabolic health and boosts microbiota. Thus, it can reduce insulin resistance and inflammation, lower bad cholesterol, improve vascular health, and boost brain health.

Bacillus Coagulans

It is a probiotic that can alter immune responses, boost intestinal production of neuropeptides, and thus promote brain health. It appears that this particular strain of probiotics is especially good for[5] boosting the production of brain growth factors. Thus, it can help manage a neural injury, improve post-inflammation repair, and increase regeneration.

Noocube Reviews: What Do Real Users Say?

It not only improved my memory but not I am sleeping much better. I also feel improved gut health. So, this is a fantastic product for brain and general wellbeing.


I have been living with diabetes and poor memory. So, I wanted to try something good for my brain and improve my blood sugar and cholesterol. This supplement works perfectly for me, and I could feel the difference after about two weeks.

Matt McCann

Great product took a little while to do its thing but stuck to it daily and it has worked a treat! It’s great feeling regular again no bloating or pains in my stomach and has improved my mental well-being overall.

David Julian

Alternatives To Noocube Review

Noocube is amazing and unique. However, one can also consider other nootropics that are quite different from Noocube.

Mind Lab Pro

Mind Lab Pro
  • Contains 11 brain boosters
  • Patented formula
  • Contains probiotics
  • Stimulant free
  • Contain herbal extract that might cause allergic reactions
  • Vitamin Bs in low-dose

Qualia Mind

Qualia Mind
  • Contains vitamins in high doses, especially B-complex
  • Contains amino acids
  • Have herbals like Gingko Biloba
  • Rich in fatty acids
  • Too many ingredients that may not mix well
  • Higher incidence of side effects

Performance Lab Mind

Performance Lab Mind
  • Ingredients are known to promote neural growth
  • Improve mitochondrial energy production
  • Stabilize cell membrane
  • Reduce mental fatigue
  • It may take longer to start acting
  • Poor availability

Health Benefits Of Noocube 

As already mentioned, Noocube is unique in that it counters the root cause of the ailing brain. This is not just good for brain cells, boosts brain function, improves mood and mental alertness, and prevents neurodegeneration, but it is also excellent for gut and metabolic health.

It works mainly by modulating the gut-brain axis, thus, improving metabolic health and the production of neurotransmitters. Additionally, it increases the production of brain growth factors and boosts regenerative processes.

It is also suitable for preventing irritable bowel syndrome, inflammatory bowel disease, diabetes, reducing cholesterol, and can help prevent Alzheimer’s disease.

Potential Side Effects

There are no known severe side effects of the Noocube. However, some of its ingredients may cause bloating and changes in appetite. Generally, these effects are short-lived and transient. Therefore, these side effects are rarely the reason for discontinuing its use.

How To Take Noocube?

It is pretty simple to use, but one needs to remember that a serving of supplements contains four capsules. Therefore, it is good to take all four capsules together. One may take them about 30 minutes before breakfast. However, they would work well even when taken in the evening.

Final Thought

There are many nootropics on the market. Most of them focus on boosting brain health. However, modern studies show that the gut is the secret to boosting brain health. Noocube is among the few nootropics influencing the gut-brain axis, preventing leaky gut, and normalizing metabolism. Thus, it can influence brain health directly and indirectly. It not only improves mood and memory but prevents neurodegeneration. Hence, it has long-term benefits for brain health, too.

Frequently Asked Questions

What is the recommended dosage?

Three capsules daily with water and food.

Is it safe?

Yes. The supplement is third-party tested, contains all-organic ingredients, and is made in GMP-approved facilities.

Can I take it on an empty stomach?

The manufacturer recommended that you take this supplement with water and heavy meals.

What are the side effects?

If you are allergic to seafood, this supplement might not be good for you.

Will it help me lose a few pounds?

This supplement’s numerous benefits include appetite control; therefore, it can help you cut weight.

Who should avoid Gundry MD Total Restore?

If you are allergic to seafood, have any underlying condition, are lactating, or are pregnant, check with your doctor before using this product.

Where can I buy Total Restore?

The company’s official website or third-party online retailer such as Amazon.

Is there a return policy?

Every product from Gundry MD comes with a 90-day money-back guarantee.

+ 5 Sources

EHproject has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We work mostly with peer-reviewed studies to ensure accurate information. We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.

  1. 2021 Alzheimer’s disease facts and figures. (2021). Alzheimer’s & Dementia, [online] 17(3), pp.327–406. doi:https://doi.org/10.1002/alz.12328.
  2. Terry, N.A. and Kara Gross Margolis (2016). Serotonergic Mechanisms Regulating the GI Tract: Experimental Evidence and Therapeutic Relevance. Handbook of experimental pharmacology, [online] pp.319–342. doi:https://doi.org/10.1007/164_2016_103.
  3. Carabotti, M., Scirocco, A., Maselli, M.A. and Severi, C. (2015). The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Annals of gastroenterology, [online] 28(2), pp.203–209. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367209/.
  4. Sotira, S., Matteo Dell’Anno, V. Caprarulo, Hejna, M., Pirrone, F., Maria Luisa Callegari, Telma Vieira Tucci and Rossi, L. (2020). Effects of Tributyrin Supplementation on Growth Performance, Insulin, Blood Metabolites and Gut Microbiota in Weaned Piglets. Animals, [online] 10(4), pp.726–726. doi:https://doi.org/10.3390/ani10040726.
  5. Jensen, G.S., Cash, H.A., Farmer, S. and Keller, D. (2017). Inactivated probiotic Bacillus coagulans GBI-30 induces complex immune activating, anti-inflammatory, and regenerative markers in vitro. Journal of Inflammation Research, [online] Volume 10, pp.107–117. doi:https://doi.org/10.2147/jir.s141660.


Rick is a Final Year Medical Student. Passionate about medicine, fitness and personal growth, he is always ready to challenge himself to accomplish tasks and especially spread correct medical information to people. Rick is a long-term… See More

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