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Best CBD Oil For Pain & Inflammation: Top 9 CBD Brands 2024

Best CBD Oil For Pain
CBD oil is one of the most effective remedies for severe chronic pain management. Photo: Team Design

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Cannabidiol, or CBD, is prevalently becoming the most sought natural remedy for pain management. CBD is derived from the cannabis plant and is used to make pain-relieving products without psychoactive effects. Unlike most pain relief remedies, such as opioids and other prescription medications, CBD oil has little to no side effects. Hemp-derived CBD products come in various forms of topical CBD products, including CBD oil tinctures, CBD gummies, capsules, CBD topicals, and many more. 

CBD products also contain different types of CBD oil, including full spectrum, broad spectrum, and CBD isolate. Full spectrum CBD oil contains all the chemical compounds in a hemp plant, including THC, offering the “entourage” effect. Broad spectrum has all the compounds in a cannabis plant except the THC, while CBD isolate contains pure CBD oil. Since there are various reasons[1] why people prefer using CBD products, the CBD industry is flooded with numerous CBD companies claiming to design the best products. This article lists and describes some of the best CBD oil companies in 2022 that offer top-notch CBD products with effective pain-relieving benefits.

Best CBD For Pain Relief: 9 Top Picks In 2024

How Does CBD Oil Help Relieve Pain?

CBD-infused products are a natural alternative for addressing chronic pain. CBD can relieve joint, back, and muscle pain as it contains anti-inflammatory properties. By stimulating the ECS, CBD oil for pain can alleviate pain and inflammation in the body. It binds the CB1 and CB2 receptors in the brain and immune system. Through this, CBD oil for pain management aids the body in modulating pain signals and producing inflammatory cytokines.

Best CBD Oil For Pain & Inflammation: Top 9 Brands Of 2024


CBDfx Oil Wellness Tincture

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  • Vegan friendly
  • Full-spectrum CBD oil
  • Non-GMO
  • Third-party tested
  • Expensive
  • Contains THC

This full-spectrum CBD oil is an excellent option for pain-relieving properties. It comes in multiple potencies that range from 500mg to 4000 mg of CBD oil. This vegan-friendly CBD oil for pain management is an excellent option if you seek to experience the “entourage” effect. If you want to avoid THC, this CBD oil is not an excellent option.


CBDistillery Full Spectrum CBD Oil

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  • Moderately priced
  • Approved by the US Hemp Authority
  • THC-free option
  • Third-party tested
  • No multiple flavors options

This CBD oil for pain comes in different types. The brand offers CBD isolate, full spectrum, and broad spectrum CBD oil. These products have a solid reputation for alleviating various health conditions, such as chronic pain and anxiety. This CBD oil for pain management is third-party tested, and all the results are available on the brand’s official website.

Joy Organics

Joy Organics Organic Broad Spectrum CBD Tincture

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  • Third-party tested
  • USDA certified organic
  • Multiple flavors and potencies
  • Comes with a 90-day money-back guarantee
  • Relatively pricey

This company offers premium full-spectrum and broad-spectrum CBD-size oils. All CBD products undergo third-party testing to guarantee efficacy, purity, and potency. This CBD brand also offers multiple flavors, including  Fresh lime, Tropical sunrise, Summer lemon, Orange bliss, Strawberry and Champagne, and Tranquil mint. These broad-spectrum and full-spectrum CBD oils come with a 90-day money-back guarantee. This brand offers some of the best CBD oils for chronic pain and other health benefits.

Spruce CBD

Spruce CBD Oil

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  • Full-spectrum CBD oil
  • Third-party laboratory testing
  • High potencies
  • Has no flavor options

Spruce offers some of the best CBD oils to manage pain. You can alleviate chronic pain in the muscles, joints, back, and many more by using this full-spectrum CBD oil. These CBD products come in high potencies ranging from 25 to 80 mg. The brand also offers a 30-day money-back guarantee.

 Savage CBD

savage cbd oil
  • Third-party tested
  • Multiple potencies
  • Multiple flavors
  • Moderately priced
  • No return policy

Savage CBD offers a vast selection of CBD oil for pain. These products come in multiple flavors, including cucumber mint, pink grapefruit, peach pear, and lemon-lime. They also come in multiple high potencies that range from 1000mg to 2000mg of CBD oil. They contain full-spectrum CBD extract that contains less than 0.3% of THC.

Royal CBD

Royal CBD Oil
  • Multiple flavors
  • Multiple potencies
  • Third-party tested
  • Uses CO2 method of extraction
  • Expensive
  • Contains THC

Royal CBD offers full-spectrum CBD oil for chronic pain. The products come in multiple potencies ranging from 500mg to  2500 mg CBD oil and various flavors, including natural, vanilla, mint, berry, and earthy. These products are third-party tested and come with a 30-day money-back guarantee. You can experience immense chronic pain relief by taking CBD oil from this company.



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  • Moderately priced
  • Third-party tested
  • Offers a 90-day money-back guarantee
  • Uses CO2 method of extraction
  • Full-spectrum
  • There are no flavor options
  • Limited production options

This CBD oil for pain management comes in multiple potencies that range from 300mg to 1000mg. This full-spectrum hemp oil undergoes third-party testing to guarantee potency, quality, and purity. This CBD oil for pain is an excellent option for anyone seeking to experience the “entourage” effect of the beneficial compounds from a cannabis plant.

Nuleaf Naturals

nuleaf naturals

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  • Uses hemp grown in the USA
  • Third-party lab tested
  • Free shipping
  • Used the C02 method of extraction
  • No multiple strengths

This CBD oil can alleviate chronic pain, inflammation, anxiety, and many more. The brand offers a full spectrum that contains all the beneficial cannabinoids in a hemp plant, including CBD, CBC, CBN,[2] and CBG. Each product comes with a 30-day money-back guarantee and is third-party tested for strength, efficacy, and purity.



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15% Off Exclusive Coupon: HEALTHCANAL

  • Third-party tested
  • Has THC-free options
  • Multiple potencies
  • Approved by US Hemp Authority
  • Restrictive return policy

This company is an excellent option if you seek CBD oil for chronic pain. It comes in multiple potencies ranging from 500mg to 6000mg. The product has multiple flavors, such as citrus, chocolate mint, and strawberry mint. You can choose from full-spectrum, CBD isolate, and broad-spectrum CBD oil. The company offers a 30-day money-back guarantee; therefore, you can return the order in case of unsatisfactory results.

What Does Research Say?

Studies show CBD oil can address various health conditions such as chronic pain, anxiety, inflammation, seizures, and many more. Epidiolex is the first CBD-infused drug with FDA approval[3] to deal with seizures associated with  Lennox-Gastaut syndrome (LGS) and Dravet syndrome. There are animal-based researches that suggest cannabidiol offers the following health benefits:

  • Reduce anxiety
  • Improve sleep quality
  • Pain management[4]
  • Alleviate inflammation
  • Lower joint pain related to arthritis pain

What Is CBD Oil?

CBD is among the numerous chemical compounds in organic hemp plants. Studies[5] show that cannabidiol offers various therapeutic health benefits. Numerous cannabinoids, including terpenes, flavonoids, THC, and many more, are present in cannabis. This is a substance that cannabinoids were used to make. It is often diluted with hemp seed or coconut oil and is not psychoactive. Many people use CBD to treat various physical and mental health issues. The main psychoactive substance that produces a “high” experience is THC. Contrarily, CBD has become one of the most well-liked all-natural treatments for easing pain and lowering tension.

How Does CBD Work?

CBD oil can offer pain management by interacting with the endocannabinoid system[6] (ECS). CBD[7] stimulates the CB1 and CB2 receptors in the endocannabinoid system. CB1 receptors are especially found in the brain and are responsible for controlling memories, appetite, thinking, mood, emotion, pain, movement, and many more. On the other hand, CB2 receptors are especially found in the immune system and affect pain and inflammation.

How Long Does It Take CBD Oil To Work For Pain?

It might take fifteen to forty-five minutes; however, this duration relies on various factors, including:

  • Form of CBD consumption, i.e., tinctures, gummies, sprays, topicals, and many more
  • CBD concentration
  • CBD dosage
  • Your body type
  • Food intake
  • Frequency of CBD consumption

How To Choose The Best CBD Oil For Pain?

If you are seeking to purchase CBD-infused products, consider the following factors:

  • Third-party testing
  • Source of CBD oil
  • Carrier oil, i.e., MCT oil, coconut oil, vegetable oil, and many more
  • CBD oil flavors
  • Customer feedback
  • Brand reputation
  • COA accessibility

Health Benefits Of CBD Oil

Taking CBD-infused products can offer the following health benefits[8]:

  • Relieving pain
  • Improving sleep quality
  • Boosting mental health by reducing PTSD, anxiety, depression, and stress symptoms
  • Alleviating pain related to cancer
  • Reducing seizures
  • Alleviating inflammation[9]
  • Combating drug addiction[10]
  • Boosting skin health[11]

Potential Side Effects

CBD-infused products can result in various side effects,[12] including:

  • Impotence in men
  • Mood swings
  • Negatively interaction with other drugs
  • Loss of appetite
  • Weight changes
  • Drowsiness
  • Nausea

Nursing and pregnant women[13] should avoid these products. People with an underlying condition or any prescribed medication should consult a healthcare provider before using these products. 


CBD oils can be consumed in various forms, and there is no standard dosage. However, if a healthcare provider medically prescribes it for controlling seizures associated with epilepsy, adhere to the recommended dosage. The proper dosage relies on various factors such as:

  • Form of CBD consumption, i.e., CBD cream, tinctures, gummies, sprays, and many more
  • CBD concentration
  • Desired result
  • Your body type
  • Food intake
  • Targeted health condition 

Final Thought

CBD-infused products are an excellent natural alternative for internal and localized pain relief. You can also use them for relieving anxiety, depression, and inflammation, improving sleep quality, reducing seizures, and many more. Nursing and pregnant women should avoid these products. People with an underlying condition or any prescribed medication should consult a healthcare provider before using these products.

Frequently Asked Questions

Is buying CBD legal?

You can purchase CBD oil, so long as it contains the legal limit of THC, 0.3%. However, CBD is illegal in some states.

Will I get high?

No. These products do not have psychoactive properties.

How long till I see results?

This depends on the method of administration. Vaping and smoking offer immediate results compared to edibles, capsules, and topicals.

What other health benefits does CBD oil offer?

Apart from relieving anxiety, these products can help reduce pain, boost brain functionality, prevent neurological diseases, manage chronic pain, and many more.

Are there any side effects?

Some users report various side effects, including diarrhea, agitation, appetite change, drowsiness, and irritability.

What is the best CBD brand?

There are many brands offering premium quality products. The ones mentioned above are among them.

What is the age limit for using CBD?

This differs from one state to another; however, you should be at least 18-21 years or older.

Are there pain CBD-infused products for pets?

Yes, these companies offer CBD pet treats and oils to relieve anxiety for pets.

+ 13 Sources

EHproject has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We work mostly with peer-reviewed studies to ensure accurate information. We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.

  1. Meissner, H. and Cascella, M. (2023). Cannabidiol (CBD). [online] Nih.gov. Available at: https://www.ncbi.nlm.nih.gov/books/NBK556048/
  2. Russo, E.B. and Marcu, J.P. (2017). Cannabis Pharmacology: The Usual Suspects and a Few Promising Leads. Advances in pharmacology, [online] pp.67–134. doi:https://doi.org/10.1016/bs.apha.2017.03.004.
  3. Office (2020). FDA Approves First Drug Comprised of an Active Ingredient Derived from Marijuana to Treat Rare, Severe Forms of Epilepsy. [online] U.S. Food and Drug Administration. Available at: https://www.fda.gov/news-events/press-announcements/fda-approves-first-drug-comprised-active-ingredient-derived-marijuana-treat-rare-severe-forms
  4. Resah, M., Narges Joshaghani, Villa, N., Badla, O., Goit, R., Saddik, S.E., Dawood, S.N., Rabih, A.M., Niaj, A., Raman, A., Manish Uprety, Maria Jose Calero and Khan, S. (2022). Efficacy, Safety, and Regulation of Cannabidiol on Chronic Pain: A Systematic Review. Cureus. [online] doi:https://doi.org/10.7759/cureus.26913.
  5. Rapin, L., Gamaoun, R., El Hage, C., Arboleda, M.F. and Prosk, E. (2021). Cannabidiol use and effectiveness: real-world evidence from a Canadian medical cannabis clinic. Journal of Cannabis Research, [online] 3(1). doi:10.1186/s42238-021-00078-w.
  6. Lu, H.-C. and Mackie, K. (2016). An Introduction to the Endogenous Cannabinoid System. Biological Psychiatry, [online] 79(7), pp.516–525. doi:10.1016/j.biopsych.2015.07.028.
  7. Zou, S. and Kumar, U. (2018). Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System. International Journal of Molecular Sciences, [online] 19(3), p.833. doi:10.3390/ijms19030833.
  8. Corroon, J. and Phillips, J.A. (2018). A Cross-Sectional Study of Cannabidiol Users. Cannabis and Cannabinoid Research, [online] 3(1), pp.152–161. doi:10.1089/can.2018.0006.
  9. Xiong, W., Cui, T., Cheng, K., Yang, F., Chen, S.-R., Willenbring, D., Guan, Y., Pan, H.-L., Ren, K., Xu, Y. and Zhang, L. (2012). Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors. Journal of Experimental Medicine, [online] 209(6), pp.1121–1134. doi:10.1084/jem.20120242.
  10. Morgan, C.J.A., Das, R.K., Joye, A., Curran, H.V. and Kamboj, S.K. (2013). Cannabidiol reduces cigarette consumption in tobacco smokers: Preliminary findings. Addictive Behaviors, [online] 38(9), pp.2433–2436. doi:10.1016/j.addbeh.2013.03.011.
  11. Oláh, A., Tóth, B.I., Borbíró, I., Sugawara, K., Szöllõsi, A.G., Czifra, G., Pál, B., Ambrus, L., Kloepper, J., Camera, E., Ludovici, M., Picardo, M., Voets, T., Zouboulis, C.C., Paus, R. and Bíró, T. (2014). Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes. Journal of Clinical Investigation, [online] 124(9), pp.3713–3724. doi:10.1172/jci64628.
  12. Iffland, K. and Franjo Grotenhermen (2017). An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies. Cannabis and cannabinoid research, [online] 2(1), pp.139–154. doi:https://doi.org/10.1089/can.2016.0034.
  13. Naik, S., Kolikonda, M., Prabhu, A. and Lippmann, S. (2018). MARIJUANA ON THE BRAIN- A CONCERN. Innovations in clinical neuroscience, [online] 15(1-2), p.12. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042982/.


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